Hepatitis

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Primary Biliary Cirrhosis

eMedicine — Overview: Primary biliary cirrhosis (PBC) is a chronic and progressive cholestatic disease of the liver. The etiology is unknown, although it is presumed to be autoimmune in nature. The major pathology of this disease is a destruction ...More…
More on Porphyria Cutanea Tarda

eMedicine — Overview: Porphyria cutanea tarda (PCT) is a term encompassing a group of disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase (UROD) is deficient.1 Porphyria cutanea tarda includes familial types with UROD gene ...More…
Vasanta P Weiss, MD,

eMedicine — Overview: Classic polyarteritis nodosa (PAN or c-PAN) is a systemic vasculitis characterized by necrotizing inflammatory lesions that affect medium and small muscular arteries, preferentially at vessel bifurcations, resulting in microaneurysm ...More…
Robert L Cirillo Jr, MD, MBA,

eMedicine — Overview: Polyarteritis nodosa (PAN) is an autoimmune systemic inflammatory vasculitis that results in transmural fibrinoid necrosis with surrounding inflammation in small and medium-size vessels. PAN commonly affects the kidneys, heart, liver, ...More…
Christine B Bernal, MD,

eMedicine — Overview: In 1866, Kussmaul and Meier first described polyarteritis nodosa (PAN), a disease of small-sized and medium-sized arteries. Although any organ can be affected, PAN most commonly involves the skin, joints, peripheral nerves, ...More…
Steve Chung, MD,

eMedicine — Overview: Polyarteritis nodosa (PAN) is a rare systemic vasculitis necrotizing vasculitis characterized by necrotizing inflammation of small- and medium-sized arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or ...More…
Pediatrics, Child Sexual Abuse

eMedicine — Overview: Child sexual abuse affects more than 100,000 children a year. Many of these children present to the emergency department (ED). The following article outlines triage determinants for examinations, examination techniques, and ...More…
Infantile Polyarteritis Nodosa

eMedicine — Overview: Infantile polyarteritis nodosa (IPAN) is a rare and often fatal inflammatory disease of small and medium arteries. Polyarteritis has been described worldwide, although vasculitic diseases tend to be more common in individuals of Asian ...More…
Kara N Shah, MD, PhD,

eMedicine — Overview: Gianotti-Crosti syndrome is a self-limited childhood exanthem that manifests in a characteristic acral distribution. It is rarely associated with systemic findings. The original cases, described in Italy by Gianotti in 1955, were ...More…
Gianotti-Crosti Syndrome

eMedicine — Overview: Gianotti-Crosti syndrome (GCS) is a distinct infectious exanthem with associated lymphadenopathy and acute anicteric hepatitis.1 Gianotti and Crosti initially described GCS as associated with a hepatitis B virus exanthem, which they ...More…
Fulminant Hepatic Failure

eMedicine — Overview: Fulminant hepatic failure (FHF) is usually defined as the severe impairment of hepatic functions in the absence of preexisting liver disease. However, unlike in adults, encephalopathy may be absent, late, or unrecognized in children. ...More…
Dermatologic Manifestations of Gastrointestinal Disease

eMedicine — Overview: Many disorders of the alimentary tract have dermatologic manifestations (see the Table below). A thorough understanding of the cutaneous/gastrointestinal (GI) relationship can alert the astute clinician to occult disease within the GI ...More…

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