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  • Prion-Related Diseases

    eMedicine — Overview: The prion diseases are a large group of related neurodegenerative conditions, which affect both animals and humans (Sadowski, 2004). Included are Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker (GSS) in humans, bovine ...More…

  • Frontal Lobe Syndromes

    eMedicine — Overview: The frontal lobe is the largest lobe in the brain, yet it is often not specifically evaluated in routine neurologic examinations. This may in part be due to the attention to detail and rigorous testing strategies ... The frontal lobe is ...More…

  • Driving and Neurological Disease

    eMedicine — Overview: Of Medical Problems And Driving Fitness Driving an automobile is an economic, social, and recreational necessity for most Americans. Driving occupies a central role in the lives of adults, especially older adults, who rely in an ...More…

  • Dementia With Lewy Bodies

    eMedicine — Overview: Frederick Lewy first described Lewy bodies (LBs), cytoplasmic inclusions found in cells of the substantia nigra in patients with idiopathic Parkinson's disease, in 1914. In the 1960s, several pathologists described patients with ...More…

  • Cortical Basal Ganglionic Degeneration

    eMedicine — Overview: Cortical basal ganglionic degeneration (CBGD) may be considered a syndrome rather than a disease. Its defining clinical characteristics (ie, progressive dementia, parkinsonism, limb apraxia) may occur as a result of heterogenous ...More…

  • Communication Disorders

    eMedicine — Overview: The Normal Communication Process Communication is a multidimensional dynamic process that allows human beings to interact with their environment. Through communication, people are able to express thoughts, needs, and emotions. ...More…

  • Apraxia and Related Syndromes

    eMedicine — Overview: Apraxia is one of the most important and least understood major behavioral neurology syndromes. It is one of the best localizing signs of the mental status examination and also predicts disability in patients with stroke or ...More…

  • Amyloidosis, Overview

    eMedicine — Overview: Definition of Amyloidosis Amyloidosis is a clinical disorder caused by extracellular deposition of insoluble abnormal fibrils that injure tissue. The fibrils are formed by the aggregation of misfolded, normally soluble proteins. In ...More…

  • Alcohol and Substance Abuse Evaluation

    eMedicine — Overview: Physicians in the emergency department (ED) regularly encounter patients seeking treatment for alcohol or substance abuse problems. The initial evaluation may seem routine, yet these patients have multiple physical and emotional issues ...More…

  • More on Progressive Supranuclear Palsy

    eMedicine — Overview: Progressive supranuclear palsy (PSP), also known as Steele-Richardson-Olszewski syndrome, is a neurodegenerative disease that affects cognition, eye movements, and posture (Golbe, 2001). PSP was first described as a clinicopathologic ...More…

  • Posttraumatic Hydrocephalus

    eMedicine — Overview: Posttraumatic hydrocephalus (PTH) is a frequent and serious complication that follows a traumatic brain injury (TBI).1, 2, 3 Its incidence varies greatly from study to study, largely based on different criteria for its diagnosis. ...More…

  • Parkinson-Plus Syndromes

    eMedicine — Overview: Definition Several primary neurodegenerative disorders have parkinsonian features, such as bradykinesia, rigidity, tremor, and gait disturbances, in common. These neurologic conditions are associated with complex clinical presentations ...More…


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